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The Messenger

Moderna, the Vaccine, and the Business Gamble That Changed the World

ebook
1 of 1 copy available
1 of 1 copy available

The inside story of an unprecedented feat of science and business.

At the start of 2020, Moderna was a biotech unicorn with dim prospects. Yes, there was the promise of its disruptive innovation that could transform medicine by using something called messenger RNA, one of the body's building blocks of life, to combat disease. But its stock was under water. There were reports of a toxic work culture. And despite ten years of work, the company was still years away from delivering its first product. Investors were getting antsy, or worse, skeptical.

Then the pandemic hit, and Moderna, at first reluctantly, became a central player in a global drama—a David to Big Pharma's Goliaths—turning its technology toward breaking the global grip of the terrible disease. By year's end, with the virus raging, Moderna delivered one of the world's first Covid-19 vaccines, with a stunningly high rate of protection. The achievement gave the world a way out of a crippling pandemic while validating Moderna's technology, transforming the company into a global industry power. Biotech, and the venture capital community that fuels it, will never be the same.

Wall Street Journal reporter Peter Loftus, veteran reporter covering the pharmaceutical and biotech industries and part of a Pulitzer Prize–finalist team, brings the inside story of Moderna, from its humble start at a casual lunch through its heady startup days, into the heart of the pandemic and beyond. With deep access to all of the major players, Loftus weaves a tale of science and business that brings to life Moderna's monumental feat of creating a vaccine that beat back a deadly virus and changed the business of medicine forever.

The Messenger spans a decade and is full of heroic efforts by ordinary people, lucky breaks, and life-and-death decisions. It's the story of a revolutionary idea, the evolution of a cutting-edge American industry, and one of the great achievements of this century.

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    • Publisher's Weekly

      June 6, 2022
      Wall Street Journal reporter Loftus charts in his captivating debut Moderna’s spectacular rise from a small biotech company with “no products no profits” in 2018 to a key player in the race for a Covid-19 vaccine. Moderna’s success, Loftus writes, was “as improbable as it was miraculous” and due to the company’s gamble on using messenger RNA in its vaccine, as regulators had never approved its use as a drug. The vaccine failing or the virus “fizzl away like past outbreaks,” he posits, would’ve been a costly misstep for the company. Instead, the company became “a household name... on track to book more than $7 billion in profit for the first nine months of 2021.” Interviewing more than 150 insiders, including CEO Stéphane Bancel, Loftus pulls back the curtain on the vaccine development process as the pandemic raged: there were threatened patent fights, political hurdles, and complex logistical challenges in trialing and distributing the vaccine to millions of people. Loftus achieves no small feat with his sharp reporting: it’s gripping from page one, despite the fact that most readers already know the outcome. This is a great look at the business of pandemic medicine. Agent: Eric Lupfer, Fletcher & Co.

    • Kirkus

      June 15, 2022
      Fast-paced account of Moderna's race to be first to market with a Covid-19 vaccine. Wall Street Journal reporter Loftus opens his narrative, an able blend of science reporting and business history, at a telling moment: Moderna CEO St�phane Bancel, on vacation in France in January 2020, reads about a mysterious virus in China and, on a dime, pivots the company to use that virus as a proof of concept for a new kind of vaccine. Moderna aimed to use messenger RNA to introduce drugs developed on a constantly adaptable platform into the human body. Though the original "stopwatch drill" that Bancel had been examining centered on a rare disease caused by the Nipah virus, he and some of his board members and executives "thought Moderna should try for a coronavirus vaccine because they suspected the outbreak would get much bigger." They were right. Coordinating the race for a vaccine that was spreading far faster than SARS, MERS, Zika, and other concerning viruses, Bancel had to take his small company to new levels of production in the face of the Trump administration's patchwork medical and financial responses. It's no small irony that a leader of the industry's rapid-response team was a Moderna board member who was both a Moroccan immigrant and a one-time Marxist who worried that chasing the vaccine could ultimately harm Moderna since other projects would have to halt. Still, as Loftus writes, "Moderna agreed to cooperate with Operation Warp Speed in part because...it needed the money." In the end, racing past regulatory and bureaucratic hurdles, it secured funding and produced a safe vaccine in record time. It also rose markedly in value, at one time surpassing Starbucks, UPS, and Citigroup. As Loftus writes in closing, Moderna has since been able to return to other quests, including genetically keyed cancer drugs that kick the immune system's neoepitopes into high gear. A satisfying look at how a smart business can both identify opportunity and do well by doing good.

      COPYRIGHT(2022) Kirkus Reviews, ALL RIGHTS RESERVED.

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